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Within the past few years, it has become recognized that the immune system communicates to the brain. Substances released from activated immune cells (cytokines) stimulate peripheral nerves, thereby signaling the brain and spinal cord that infection/inflammation has occurred. Meer
Airways inflammation is a complex biological phenomenon resulting from
the recruitment and activation of numerous cell types. Airways
inflammation contributes to the pathophysiology of airways disease. Meer
Rheumatoid arthritis (RA) is the most common and most severe form of inflammatory arthritis. The pathogenesis of RA has been the subject of intense research for several decades. Meer
Gene therapy for inflammatory diseases is a new , burgeoning field of
medicine. Edited by the undisputed pioneers of this area of research,
this volume is the first devoted to its topic. Meer
This volume describes recent research in the field of metalloproteinases (a family of enzymes that can catalyze tissue degradation), in particular their participation in autoimmune diseases such as rheumatoid arthritis, reviewing the latest developments in metalloproteinase inhibitor design and the current status of clinical candidates. Meer
Pain and inflammation are inextricably linked phenomena. The observation that chemical mediators with combined pro-inflammatory, algesic and/or hyperalgesic activity occur at the site of inflammation is fundamental not only to our present understanding of the inflammatory process but also to our attempts to devise clini cally useful anti-inflammatory therapies. Meer
t Heinz Red! and Gunther Sch!ag Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria The word "sepsis" derives from the Greek meaning decay or rottenness. Meer
Over the past ten years, a number of cytokines and growth factors have
proven to be as effective therapeutics. While these products have
certainly established recombinant biologics as a major pharmaceutical
growth sector, the continued interest in this class of drugs arises from
the fact that today we have a far better understanding of the human
immune response, both at a cellular and molecular level. Meer
Many new antileukotriene drugs are now marketed as antiasthma drugs and
represent the first new drugs in this field since the 1970s. This book
covers the steps that have led to the discovery and development of these
new drugs and offers detailed descriptions of their clinical
applications. Meer
Recombinant protein drugs are intimately associated with the impressive
success story of the Biotech Industry during the past thirty years, some
of them belonging to the most successful pharmaceutical products. Meer
Sildenafil, for the treatment of erectile dysfunction, is one of the first products that has made its way successfully from basic NO (nitrous oxide) research, to clinical routine therapy. Meer
Modern adhesive dentistry has numerous applications in cariology, as well as in aesthetic and pediatric dentistry, prosthodontics, implantology, and orthodontics—in essence, in comprehensive dental care. Meer
In man and some of the apes, the thumb has the function of a contra finger. This function is made possible by a great freedom of movement of the first metacarpal and a highly developed and differentiated thumb musculature. Meer
1. Would a better understanding of the anatomy and improvement of the method make it possible to reduce the percentage of failures sufficiently to earn selective arteriography of bronchial and intercostal arteries a place among the accepted methods of selective arteriographic investigation? Meer
The interplay between the careful analysis of clinical electrocardiograms and results from animal experiments have in the past 60 years resulted in provo cative and brill ant concepts on the mechanisms of cardiac arrhythmias in man. Meer
Our knowledge of the diseases of the small intestine has increased greatly since the second world war. The advances made in the auxiliary sciences, in particular biochemistry and histology, are mainly responsible and have led to their increased importance in this field. Meer
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